Modalert 200 mg Tablet has a mood-enhancing effect and has been tested in patients with depression. It is not recommended for long-term use. It has a high abuse potential and should be taken with caution in people with a history of alcohol or drug abuse.

The medicine may interact with blood thinners like warfarin. This can increase the risk of bleeding. It should be avoided in people with a history of liver problems.

It is used to treat excessive daytime sleepiness (narcolepsy)

Modalert (Modawake 200) is an orally administered benzhydryl sulfinylacetamide non-amphetamine stimulant. It has been shown to improve alertness in patients with narcolepsy. In two large, randomized, double-blind placebo-controlled studies (with a total of 554 patients), modafinil showed significant improvements in subjective measures of wakefulness and objective measures of alertness. It is also effective in treating sleepiness associated with shift work disorder.

It is used in conjunction with breathing devices and other treatments to help prevent excessive daytime sleepiness in people who have narcolepsy or shift work sleep disorder. It is also a popular off-label drug for attention deficit hyperactivity disorder (ADHD). It is not approved for use in ADHD, but it has been found to reduce symptoms of impulsivity in some studies.

Modalert can interact with several medications, including anticoagulants ('blood thinners') such as warfarin (Coumadin); monoamine oxidase inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); and drugs that affect the frontal cortex of the brain such as clonidine (Catapres). It can also cause severe or life-threatening reactions in people with certain genetic disorders.

In one study, a relatively short auditory P300 latency was associated with response to modafinil in narcolepsy patients. The medication has also been shown to relieve fatigue in multiple sclerosis patients. However, it is important to note that these results were obtained in a small sample of patients.